“Metabolic regulation of endothelial growth state”

“Angiogenesis – the growth of new blood vessels from pre-existing vasculature – is traditionally viewed from the perspective of how endothelial cells coordinate migration and proliferation in response to growth factor stimulation. However, endothelial cells must also coordinate their metabolism and adapt metabolic fluxes to the rising energy and biomass demands of sprouting vessels. Recent studies have highlighted the importance of such metabolic regulation in the endothelium and uncovered core metabolic pathways and mechanisms of regulation that drive the angiogenic process. In this presentation, current principles of endothelial metabolic regulation will be discussed. A particular focus will be given to the role of metabolite signaling and its role in controlling endothelial growth state.”

 

Michael Potente

Max Planck Institute for Heart and Lung Research, Germany