LMS Seminar- Professor Gerald de Haan
Epigenetic Regulation of Hematopoietic Stem Cell Self-Renewal
Hematopoietic stem cells provide all the blood cells in the circulation. These primitive cells must carefully regulate the balance between selfrenewal and differentiation, to ensure lifelong homeostasis. During aging hematopoietic stem cells lose functional potential. In our studies we identified a critical and unique role of CBX7 (one of the Polycomb group genes) as a regulator of selfrenewal, both in mice and man. We show how CBX7 interacts non-canonically with various H3K9 methyltransferases, and find that genetic or pharmacological inhibition of CBX7 induces differentiation in leukemic stem cells.