LMS WIP Seminar – Claudia Lennicke
“Redox-dependent regulation of the transcription factor FOXO in metabolism and ageing”
The aim of my project is to study how redox regulation of FOXO impacts metabolism and ageing. We are using the fruit fly Drosophila melanogaster as a model system, and have generated a series of specific knock-in lines where the redox-reactive cysteine residues in FOXO are replaced by redox-inert serines. Detailed phenotyping of these redox-modified FOXO flies, from transcriptional activity to physiological effects, will provide a comprehensive molecular analysis of FOXO redox regulation in vivo.