LMS WIP Seminar – Michelle Percharde
“Exploring chromatin and transposable element regulation in development and disease”
Transposable elements (TEs) make up approximately half of mammalian genomes and are subject to multilayered mechanisms of regulation that are poorly understood. Surprisingly, several TE families are highly expressed in early development, as well as in specific cases of disease. I will summarise my previous research describing novel roles for LINE1 retrotransposons in early mouse development. I will also discuss our group’s latest findings and future avenues, as we aim to understand the chromatin-based regulation of TEs in development, as well as their contrasting roles in development vs disease.
Chromatin and Development group