“Computing and Bioinformatics work in partnership with all the research groups and facilities at the LMS to deliver cutting edge science.”

The facility provides IT and bioinformatics support for state-of-the art scientific equipment and research. It encompasses high performance computing facilities, an IT service desk and bioinformatics and informatics support services.

Computing Support Services

  • The service desk provides support for Windows, Linux and Mac platforms.
  • The High Performance Computer clusters provide parallel computing resources for intensive image processing, statistical and genomic sequence analysis.
  • There is a fast network access within the LMS to Imperial College computational facilities such as the London e-Science Centre and to the Internet.
  • The facility provides specialist computing solutions, and extensive backup and archiving services to support scientific equipment and research activities.

Bioinformatics

  • Bioinformatics advice and assistance for data analysis across the LMS research sections; encompassing support for genomic, proteomic and epigenetic data.
  • Informatics support for the development of biological databases and software applications.
  • Support for high performance computing and algorithm development.
  • Providing and co-ordinating LMS bioinformatics resources for researchers.
  • Training and support for data analysis, bioinformatics software, packages and databases.
  • Bioinformatics Group webpage

Selected Publications

Ferreirós-Vidal, I., Carroll, T., Taylor, B., Terry, A., Liang, Z., Bruno, L., Dharmalingam, G., Khadayate, S., Cobb, B. S., Smale, S. T., Spivakov, M., Srivastava, P., Petretto, E., Fisher, A. G., & Merkenschlager, M. (2013). Genome-wide identification of ikaros targets elucidates its contribution to mouse b-cell lineage specification and pre-B-cell differentiation. Blood, 121(10), 1769-1782.

Carlos, J., Banito, A., Wuestefeld, T., Georgilis, A., Janich, P., Morton, J. P., Athineos, D., Kang, T.-W. W., Lasitschka, F., Andrulis, M., Pascual, G., Morris, K. J., Khan, S., Jin, H., Dharmalingam, G., Snijders, A. P., Carroll, T., Capper, D., Pritchard, C., Inman, G. J., Longerich, T., Sansom, O. J., Aznar, S., Zender, L., & Gil, J. (2013). A complex secretory program orchestrated by the inflammasome controls paracrine senescence. Nature Cell Biology, 15(8), 978-990.

Chan, P. K., Torres, R., Yandim, C., Law, P. P., Khadayate, S., Mauri, M., Grosan, C., Chapman-Rothe, N., Giunti, P., Pook, M., & Festenstein, R. (2013). Heterochromatinization induced by GAA-repeat hyperexpansion in friedreich’s ataxia can be reduced upon HDAC inhibition by vitamin B3. Human Molecular Genetics, 22(13), 2662-2675.