Further information about research: https://www.imperial.ac.uk/people/vincenzo.depaola
We study the regulation of neural network connectivity and function in the neocortex, a brain region affected in numerous developmental and degenerative diseases as well as acute injuries, which are incurable to date. Specifically, we are trying to understand basic principles of synaptic development and plasticity by visualizing and manipulating both rodent and, more recently, human cortical circuits directly in the living brain. We believe this knowledge is ultimately important to enhance the brain regenerative potential and understand “what goes wrong” in the numerous conditions affecting synapses, collectively called synaptopathies, which include neuropsychiatric conditions such as autism and schizophrenia as well as neurodegenerative ones such as Alzheimer’s disease. The team uses a multidisciplinary approach, at the interface between neuroscience, genetics, human stem cell and tissue biology and high-resolution optical imaging. For more information visit our web page www.DePaolaLab.com.