ProfessorGuyRutter

Faculty of Medicine, Department of Medicine

Visiting Professor

Contact

+44 (0)20 7594 3340g.rutter Website

Location

ICTEM buildingHammersmith Campus

Summary

Job Title: Professor of Cell Biology and Functional Genomics

Research: Signal transduction in the pancreatic β-cell in health and disease - my chief focus is in using functional genomics at the cellular and whole organism level to dissect the role of genes associated with Type 2 diabetes.

Brief Biosketch: After studying for a PhD in Bristol with Dick Denton FRS on mitochondrial Ca² signalling, I subsequently worked on the pancreatic β-cell as an MRC travelling Fellow with Claes Wollheim in Geneva. There, working collaboratively with Tullio Pozzan and Rosario Rizzuto in Padua, I established new approaches to exploring the control of insulin release at the single cell level through the use of recombinant target probes and other techniques. I then returned to Bristol, becoming a full Professor of Biochemistry in 2002, and moved to Imperial College in 2006.

My current research is supported by Wellcome Trust Senior Investigator and Royal Society Wolfson Merit Awards, by UK Research Council and Diabetes UK grants, as well as by the European Commission Innovative Medicines Initiative in Diabetes (IMIDIA).

Prizes and Awards: I was awarded the Minkowski Prize of the European Association for the Study of Diabetes in 2004, the Juvenile Diabetes Research Foundation's Mary Jane Krugel Award (2005), a Royal Society Wolfson Research Merit Award (2011), a Wellcome Trust Senior Investigator Award (2012) and the Dorothy Hodgkin Lecturehip of Diabetes UK (2014).

Recent Publications

Research Support. Supported by Programme and other grants from the Wellcome Trust, MRC, DUK, JDRF, BBSRC, NIH, BHF and EU.

Related links to Section of Cell Biology and Functional Genomics

Publications

Journals

Slieker RC, Münch M, Donnelly LA, et al.Slieker RC, Münch M, Donnelly LA, Bouland GA, Dragan I, Kuznetsov D, Elders PJM, Rutter GA, Ibberson M, Pearson ER, 't Hart LM, van de Wiel MA, Beulens JWJ close, 2024, An omics-based machine learning approach to predict diabetes progression: a RHAPSODY study., Diabetologia, Vol:67, Pages:885-894

Cuozzo F, Viloria K, Shilleh AH, et al.Cuozzo F, Viloria K, Shilleh AH, Nasteska D, Frazer-Morris C, Tong J, Jiao Z, Boufersaoui A, Marzullo B, Rosoff DB, Smith HR, Bonner C, Kerr-Conte J, Pattou F, Nano R, Piemonti L, Johnson PRV, Spiers R, Roberts J, Lavery GG, Clark A, Ceresa CDL, Ray DW, Hodson L, Davies AP, Rutter GA, Oshima M, Scharfmann R, Merrins MJ, Akerman I, Tennant DA, Ludwig C, Hodson DJ close, 2024, LDHB contributes to the regulation of lactate levels and basal insulin secretion in human pancreatic β cells., Cell Rep, Vol:43

Yu V, Yong F, Marta A, et al.Yu V, Yong F, Marta A, Khadayate S, Osakwe A, Bhattacharya S, Varghese S, Chabosseau P, Tabibi S, Chen K, Georgiadou E, Parveen N, Suleiman M, Stamoulis Z, Marselli L, De Luca C, Tesi M, Ostinelli G, Delgadillo-Silva L, Wu X, Hatanaka Y, Montoya A, Elliott J, Bhavik P, Demchenko N, Whilding C, Hajkova P, Shliaha P, Kramer H, Ali Y, Marchetti P, Sladek R, Dhawan S, Withers D, Rutter G, Millership S close, 2024, Differential CpG methylation at Nnat in the early establishment of beta cell heterogeneity, Diabetologia, ISSN:0012-186X

Li S, Dragan J, Tran VDT, et al.Li S, Dragan J, Tran VDT, Fung CH, Kuznetsov D, Hansen MK, Beulens JWJ, Hart LMT, Slieker RC, Donnelly LA, Gerl MJ, Klose C, Mehl F, Simons K, Elders PJM, Pearson ER, Rutter G, Ibberson M close, 2024, Multi-omics subgroups associated with glycaemic deterioration in type 2 diabetes: an IMI-RHAPSODY study, Frontiers in Endocrinology, Vol:15, ISSN:1664-2392

Rutter G, Ghiasi S, 2024, Proinflammatory Cytokines Suppress Nonsense-Mediated RNA Decay to Impair Regulated Transcript Isoform Processing in Pancreatic β-Cells, Frontiers in Endocrinology, ISSN:1664-2392

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