MRC Postdoctoral Research Scientist - Computational Regulatory Genomics
MRC Postdoctoral Research Scientist – LMS 976
Computational Regulatory Genomics – Long-range transcriptional regulation
3 Years fixed term
MRC Band 4 Salary £35,340 – £38,181 pa inclusive*
London, UK
We are looking for an enthusiastic, creative, ambitious and skilled postdoctoral scientist with background in biological sequence analysis, comparative genomics and/or analysis of next-generation sequencing-based experiments. A competitive publication record in the field is expected, as well as knowledge of molecular biology and evidence of proficiency in the computational analysis of biological data or the development of computational tools for given purpose. Proficiency in bioinformatics programming is required. Experience in R/Bioconductor programming and applied statistics are a plus. The post is open for candidates wishing to pursue a career in computational genomics in collaboration with experimental researchers, and to candidates who wish to combine experimental and computational approaches in their own work. For candidates wishing to combine experimental and computational techniques, we are looking for expertise in experimental genomic techniques. The candidate should have a strong interest in bioinformatics. Previous experience in computational analyses is an advantage.
The project will broadly focus on studying long-range transcriptional regulation and promoter-enhancer interactions in Metazoan genomes. Its aims will be to understand how genes interact with their regulatory elements at long distances, how long-range regulatory elements evolve and/or how they are affected by extracellular signals during development and differentiation. The research is expected to be based on novel approaches for the analysis of original and published comparative genomic, epigenomic, transcription factor binding and chromatin conformation experimental to investigate long-range regulation at genome-wide level.
The post supports post-doctoral scientists in early or changed career training and helps establish them as successful research scientists in their chosen field. It comes with funding for computing, consumables, training courses and travel.
LMS is an institute funded by MRC and is a division of the Faculty of Medicine at Imperial College London. Based on the Hammersmith Hospital Campus in West London, the LMS has first class facilities and provides investigators from clinical and basic science backgrounds with the opportunity to pursue innovative, multidisciplinary research within the established clinical base of Imperial College. For more information, visit www.lms.mrc.ac.uk.
