Juanma Vaquerizas

About me

Experience:

2021 -

Present

Professor of Developmental & Regulatory Genomics (Imperial College London)

2021 -

Present

Programme Leader (MRC LMS)

2012 -

2021

Group Leader (Max Planck Institute for Molecular Biomedicine, Muenster, Germany)

2008 -

2012

Postdoc (EMBL-EBI, UK)

2003 -

2008

PhD Molecular Biology (Universidad Autonoma de Madrid, Spain, & EMBL-EBI,UK)

1998 -

2003

BA & MA in Molecular Biology & Biochemistry (Universidad Autonoma de Madrid, Spain)

Research focus:

At LMS, our primary research areas encompass the study of genome function, early embryonic development, and cell fate determination. In particular, we focus on exploring the organisation of the 3D genome and other epigenetic mechanisms, supported by advanced computational and genome-wide tools. Our work is rooted in the pursuit of scientific understanding and innovation to drive medically-relevant research.

Joined LMS:

2019

About me:

I joined LMS because it's the ultimate destination for scientific exploration. Nestled in the vibrant heart of London, it offers cutting-edge facilities and a close-knit community of brilliant minds. Here, I've found not just colleagues, but friends, making it the perfect place to thrive in the world of science.

My awards and achievements:

Chair in Developmental and Regulatory Genomics - Imperial College London
Academy of Medical Sciences Professorship
MRC Investigator

Impact of my work:

Our work plays a crucial role in advancing our understanding of basic genome and cell function, with significant implications across scientific disciplines, for example highlighted by our recent research on human spermatogenesis. Furthermore, we are dedicated to nurturing the next generation of researchers in both basic and clinical fields and actively support our scientific community.

My Research

Developmental epigenomics

We aim to understand how cells use their genetic information throughout development, and how these regulatory mechanisms are affected in disease.

VIEW MY RESEARCH GROUP

Selected publications

Chang NC, Rovira Q, Wells JN, Feschotte C, Vaquerizas JM. Zebrafish transposable elements show extensive diversification in age, genomic distribution, and developmental expression. Genome Res. 2022 Jan 5:gr.275655.121. doi: 10.1101/gr.275655.121.

Ing-Simmons E, Rigau M, Vaquerizas JM. Curr Opin Cell Biol. 2022 Emerging mechanisms and dynamics of three-dimensional genome organisation at zygotic genome activation. Jan 19;74:37-46. doi: 10.1016/j.ceb.2021.12.004.

Ing-Simmons E, Vaid R, Bing XY, Levine M, Mannervik M, Vaquerizas JM. (2021). Independence of chromatin conformation and gene regulation during Drosophila dorsoventral patterning. Nature Genetics 53(4):487-499. doi: 10.1038/s41588-021-00799-x. PMID: 33795866; PMCID: PMC8035076.

This research featured on the front cover: https://www.nature.com/ng/volumes/53/issues/4

Kruse K, Hug CB, Vaquerizas JM. (2020). FAN-C: a feature-rich framework for the analysis and visualisation of chromosome conformation capture data. Genome Biology 21(1):303. doi: 10.1186/s13059-020-02215-9. PMID: 33334380; PMCID: PMC7745377.

Rhodes JDP, Feldman A, Hernandez-Rodriguez B, Diaz N, Brown JM, Fursova NA, Blackledge NP, Prathapan P, Dobrinic P, Huseyin MK, Szczurek A, Kruse K, Nasymth KA, Buckle VJ, Vaquerizas JM, Klose RJ. (2020). Cohesin disrupts Polycomb-dependent chromosome interactions in embryonic stem cells. Cell Reports, doi: 10.1016/j.celrep.2019.12.057.

Galan S, Machnik N, Kruse K, Díaz N, Marti-Renom MA, Vaquerizas JM. (2020). CHESS enables quantitative comparison of chromatin contact data and automatic feature extraction. Nature Genetics 52(11):1247-1255. doi: 10.1038/s41588-020-00712-y. PMID: 33077914; PMCID: PMC7610641.

Ing-Simmons E, Vaquerizas JM. (2019). Visualising three-dimensional genome organisation in two dimensions. Development, doi: 10.1242/dev.177162.

Diaz N, Kruse K, Erdmann T, Staiger AM, Ott G, Lenz G, Vaquerizas JM. (2018). Chromatin conformation analysis of primary patient tissue using a low input Hi-C method. Nature Communications, doi: 10.1038/s41467-018-06961-0.

Hug CB, Grimaldi AG, Kruse K, Vaquerizas JM. (2017). Chromatin architecture emerges during zygotic genome activation independent of transcription. Cell, doi: 10.1016/j.cell.2017.03.024

Vaquerizas JM, Torres-Padilla M. (2016). Developmental biology: Panormaic views of the early epigenome. Nature, doi: 10.1038/nature19468.

Vaquerizas JM, Kummerfeld SK, Teichmann SA, Luscombe NM. (2009). A census of human transcription factors: function, expression and evolution. Nature Reviews Genetics, doi: 10.1038/nrg2538.

View Pub Med View ORCiD View Google Scholar