Research Support

Research Support

We have a range of instrument platforms to enable LC-MS, GC-MS and MALDI- MSI analysis. We invest time in consulting users to ensure the best sample preparation and data interpretation for their experiments.

Services

Services

We have capabilities to provide targeted metabolomics and stable isotope labelling, as well as broader metabolite profiling across a range of sample types, and can advise on the best approach to answer a particular scientific question

Equipment

Equipment

  • Q Exactive classic coupled to Vanquish LC
  • Q Exactive plus coupled to AP-SMALDI5 AF transmission source
  • Waters TQ-XS triple quadrupole coupled to ACQUITY Premier System with 2DLC Technology
  • Agilent 8890/5987B GC-MS fitted with a Gerstel MPS Autosampler

Meet the team

Impact

We support all LMS projects which involve metabolomics analysis.

Selected publications

Newton H, Wang YF, Camplese L, Mokochinski JB, Kramer HB, Brown AEX, Fets L, Hirabayashi S. (2020). Systemic muscle wasting and coordinated tumour response drive tumourigenesis. Nat Commun. 11(1), 4653

 

Djeghloul D, Patel B, Kramer H, Dimond A, Whilding C, Brown K, Kohler AC, Feytout A, Veland N, Elliott J, Bharat TAM, Tarafder AK, Löwe J, Ng BL, Guo Y, Guy J, Huseyin MK, Klose RJ, Merkenschlager M, Fisher AG. (2020). Identifying proteins bound to native mitotic ESC chromosomes reveals chromatin repressors are important for compaction. Nat Commun. 11(1):4118

 

Porreca RM, Herrera-Moyano E, Skourti E, Law PP, Gonzalez Franco R, Montoya A, Faull P, Kramer H, Vannier JB. (2020). TRF1 averts chromatin remodelling, recombination and replication dependent-break induced replication at mouse telomeres. Elife. 9, e49817

 

van Dam E, van Leeuwen LAG, Dos Santos E, James J, Best L, Lennicke C, Vincent AJ, Marinos G, Foley A, Buricova M, Mokochinski JB, Kramer HB, Lieb W, Laudes M, Franke A, Kaleta C, Cochemé HM. (2020) Sugar-Induced Obesity and Insulin Resistance Are Uncoupled from Shortened Survival in Drosophila. Cell Metab. 31(4), 710