Animals in research
Using animal models in research is still a necessity in many areas of scientific research. Animal models allow us to understand more about ourselves as humans; how we function, how our medicine affects us, and how we could potentially treat certain diseases.
We know that exemplary animal care is essential – not just for the robustness and accuracy of our scientific findings, but because we are dedicated to ensuring our research is as ethical as possible.
Wherever possible, LMS scientists use cells and cell lines cultured in the laboratory, or computer based approaches. They may also use invertebrate models, such as fruit flies and worms.
We only use animal models where absolutely necessary, and do so in accordance with the UK’s Home Office regulations, which are widely regarded as some of the strictest in the world.
Our work involving animals is of the highest standard
Find out more
The Home Office publishes annual reports detailing all of the procedures that take place in Great Britain that involve animal testing.
The 2022 report is available to read on the Home Office website.
All work involving animals at the LMS is undertaken by fully trained staff under the governance of Imperial College London, and in accordance with Government guidelines under the Animals (Scientific Procedures) Act.
Imperial College London holds a Home Office establishment licence for animal research, and each researcher who works with animals and each new project involving animals requires a separate Home Office licence.
The Home Office will only authorise a project licence to carry out scientific procedures following comprehensive project evaluation, and require the implementation of the principles of replacement, reduction and refinement (the 3Rs) in those projects.
Our commitment to openness and transparency in using animals in research
The scientific community, including the LMS, understands how essential openness and transparency is when it comes to animal research.
The LMS’s parent organisations, the Medical Research Council and Imperial College London, have signed the UK Concordat on Openness on Animal Research. Alongside 127 UK organisations, the LMS is committed to help the public understand more about animal research.
How our work is regulated
At the LMS, animal research lies under the auspices of the UK government licence of Imperial College London. The UK regulatory and licensing system is widely recognised as one of the most stringent in the world, and a key tenet of it is animal welfare. You can read more about animal research at Imperial, including policies here.
What are the 3Rs?
The 3Rs stands for three key principles that underpin ethical animal research: Replacement, Reduction and Refinement.
Developed more than 50 years ago to provide a framework for animal research, they are now permanently embedded in national and international animal research legislation.
Replacement
Avoid or replace the use of animals in research where possible. Researchers are also developing new tools and technologies that could replace the need for animal use in testing.
Reduction
Minimise the number of animals used, through appropriately designing and analysing animal experiments.
Refinement
Minimising the pain and suffering of animals used in testing, through care, attention and the development of new techniques that prioritise animal welfare.