Metabolism in Immunity, Cancer and Ageing (MICA) Group

AMPK, or AMP-activated protein kinase, is an ancient energy sensor that monitors cellular energy levels by inhibiting energy-consuming processes and promoting energy-generating pathways. As a central regulator of metabolism and energy balance, AMPK influences multiple aspects of mitochondrial homeostasis – the process of maintaining the functioning and health of mitochondria, which are found inside cells and are essential for energy production and cell function.

“AMPK is critical to energy homeostasis and its role in metabolic conditions like obesity and diabetes is well-established but much less is known about its involvement in other physiological processes and diseases,” says Nazma, “my recent work uncovered the long-sought mechanism by which AMPK mediates mitochondrial biogenesis as part of its function in maintaining energy balance. This discovery has opened several avenues for research with potential implications in immunity and ageing.”

Using a combination of advanced techniques including CRISPR/Cas9 gene editing, proteomics,transcriptomics and biochemical techniques Nazma’s team will focus on deciphering how AMPK and mitochondrial pathways affect innate and adaptive immunity, particularly within the tumour microenvironment. Although cancer immunotherapy, such as immune checkpoint blockade, has revolutionized cancer treatment, most patients do not respond. Evidence suggests that energy dysregulation may impact various aspects of the immune response. Nazma says, “I hope that in the coming years, my work will underscore the need for developing clinical AMPK activators and demonstrate the translational benefits that could be achieved.”

Nazma has joined the LMS from the Salk Institute in San Diego, California where she was a postdoctoral fellow in Professor Reuben Shaw’s group. “I’m thrilled to join the LMS, which is home to some of the top scientists in the metabolism field. I’m particularly excited about the institute’s focus on translational research and multimorbidity, which provides the perfect environment for my work on the energy sensor AMPK and its potential impact on multiple diseases,” says Nazma, “I was also inspired by our Director, Professor Wiebke Arlt, who is not only an incredible leader but also a strong female role model dedicated to promoting equal opportunities.”

We are delighted that Nazma has joined the LMS to establish her first independent research group. Her research will help shape our understanding of the role metabolism plays in immunity, multimorbidity and ageing in the coming years.