The DNA Replication group at the LMS was formed in 2006. The team, led by Christian Speck, researches fundamental principles in DNA replication, and how this process contributes to chromatin organisation, genome architecture and transcriptional regulation. We use this knowledge to understand the molecular basis of disease and to develop novel cancer therapies.

We develop and apply single-molecule microscopy approaches to image and investigate epigenetic mechanisms involved in human diseases, such as cancer and neurodegenerative disorders, and to interrogate the structural dynamics of protein complexes from the molecule to cellular level.