The facility collaborates with users in planning and executing research involving all types of metabolomics analysis.
We have a range of instrument platforms to enable LC-MS, GC-MS and MALDI- MSI analysis. We invest time in consulting users to ensure the best sample preparation and data interpretation for their experiments.
We have capabilities to provide targeted metabolomics and stable isotope labelling, as well as broader metabolite profiling across a range of sample types, and can advise on the best approach to answer a particular scientific question
This facility is available to LMS staff and students, and external researchers.
Please contact us for pricing, availability and support with experimental design.
Sample submissions: eren.akademir@lms.mrc.ac.uk, General enquiries:l.fets@lms.mrc.ac.uk, Admin contact: Fernanda Pinto de Almeida
We support all LMS projects which involve metabolomics analysis.
Newton H, Wang YF, Camplese L, Mokochinski JB, Kramer HB, Brown AEX, Fets L, Hirabayashi S. (2020). Systemic muscle wasting and coordinated tumour response drive tumourigenesis. Nat Commun. 11(1), 4653
Djeghloul D, Patel B, Kramer H, Dimond A, Whilding C, Brown K, Kohler AC, Feytout A, Veland N, Elliott J, Bharat TAM, Tarafder AK, Löwe J, Ng BL, Guo Y, Guy J, Huseyin MK, Klose RJ, Merkenschlager M, Fisher AG. (2020). Identifying proteins bound to native mitotic ESC chromosomes reveals chromatin repressors are important for compaction. Nat Commun. 11(1):4118
Porreca RM, Herrera-Moyano E, Skourti E, Law PP, Gonzalez Franco R, Montoya A, Faull P, Kramer H, Vannier JB. (2020). TRF1 averts chromatin remodelling, recombination and replication dependent-break induced replication at mouse telomeres. Elife. 9, e49817
van Dam E, van Leeuwen LAG, Dos Santos E, James J, Best L, Lennicke C, Vincent AJ, Marinos G, Foley A, Buricova M, Mokochinski JB, Kramer HB, Lieb W, Laudes M, Franke A, Kaleta C, Cochemé HM. (2020) Sugar-Induced Obesity and Insulin Resistance Are Uncoupled from Shortened Survival in Drosophila. Cell Metab. 31(4), 710