Metabolomics facility

Research support

Our instrumentation covers a range of mass spectrometry techniques, including LC-MS, GC-MS and MALDI-MSI enabling high-resolution, quantitative and spatial metabolomics. We collaborate with research groups to develop metabolomics strategies tailored to their biological questions.

Services

Our expertise covers targeted and discovery-based metabolomics and lipidomics, as well as stable isotope-labelling experiments, across diverse biological systems. We work closely with researchers from experimental design through to data analysis, ensuring that results are robust and aligned with the scientific question.

Equipment

Q Exactive classic coupled to Vanquish LC
Q Exactive plus coupled to AP-SMALDI5 AF transmission source
Waters TQ-XS triple quadrupole coupled to ACQUITY Premier System with 2DLC Technology
Agilent 8890/5977B GC-MS fitted with a Gerstel MPS Autosampler

Meet the team

This facility is available to LMS staff and students, and external researchers.
Please contact us for pricing, availability and support with experimental design.

General enquiries:

Mariana Silva Dos SantosHead of the Metabolomics Facility

Muhammad Zaki SyedMetabolomics scientist Eren AkademirMetabolomics Scientist

If you're interested in joining the LMS

Impact

We support all LMS projects which involve metabolomics analysis.

Selected publications

Newton H, Wang YF, Camplese L, Mokochinski JB, Kramer HB, Brown AEX, Fets L, Hirabayashi S. (2020). Systemic muscle wasting and coordinated tumour response drive tumourigenesis. Nat Commun. 11(1), 4653

Djeghloul D, Patel B, Kramer H, Dimond A, Whilding C, Brown K, Kohler AC, Feytout A, Veland N, Elliott J, Bharat TAM, Tarafder AK, Löwe J, Ng BL, Guo Y, Guy J, Huseyin MK, Klose RJ, Merkenschlager M, Fisher AG. (2020). Identifying proteins bound to native mitotic ESC chromosomes reveals chromatin repressors are important for compaction. Nat Commun. 11(1):4118

Porreca RM, Herrera-Moyano E, Skourti E, Law PP, Gonzalez Franco R, Montoya A, Faull P, Kramer H, Vannier JB. (2020). TRF1 averts chromatin remodelling, recombination and replication dependent-break induced replication at mouse telomeres. Elife. 9, e49817

van Dam E, van Leeuwen LAG, Dos Santos E, James J, Best L, Lennicke C, Vincent AJ, Marinos G, Foley A, Buricova M, Mokochinski JB, Kramer HB, Lieb W, Laudes M, Franke A, Kaleta C, Cochemé HM. (2020) Sugar-Induced Obesity and Insulin Resistance Are Uncoupled from Shortened Survival in Drosophila. Cell Metab. 31(4), 710

Metabolomics