Research Support

Research Support

We perform all types of proteomics LC-MS to address the biological questions of LMS researchers. We also invest a lot of time in consulting users on sample preparation and data interpretation.

Services

Services

We perform targeted, DIA and isobraic mass tagging analysis for various research questions including general proteomics profiling, post-translational modifications quantitation.

Equipment

Equipment

  • Orbitrap Fusion Lumos with FAIMS module couple to Ultimate 3000
  • Orbitrap Exploris 240 coupled to Ultimate 3000
  • Q Exactive HF-X couple to Ultimate 3000
  • Andrew+ Pipetting Robot

Meet the team

Impact

We support all LMS projects which involve proteomics analysis.

Selected publications

Newton H, Wang YF, Camplese L, Mokochinski JB, Kramer HB, Brown AEX, Fets L, Hirabayashi S. (2020). Systemic muscle wasting and coordinated tumour response drive tumourigenesis. Nat Commun. 11(1), 4653

 

Djeghloul D, Patel B, Kramer H, Dimond A, Whilding C, Brown K, Kohler AC, Feytout A, Veland N, Elliott J, Bharat TAM, Tarafder AK, Löwe J, Ng BL, Guo Y, Guy J, Huseyin MK, Klose RJ, Merkenschlager M, Fisher AG. (2020). Identifying proteins bound to native mitotic ESC chromosomes reveals chromatin repressors are important for compaction. Nat Commun. 11(1):4118

 

Porreca RM, Herrera-Moyano E, Skourti E, Law PP, Gonzalez Franco R, Montoya A, Faull P, Kramer H, Vannier JB. (2020). TRF1 averts chromatin remodelling, recombination and replication dependent-break induced replication at mouse telomeres. Elife. 9, e49817

 

van Dam E, van Leeuwen LAG, Dos Santos E, James J, Best L, Lennicke C, Vincent AJ, Marinos G, Foley A, Buricova M, Mokochinski JB, Kramer HB, Lieb W, Laudes M, Franke A, Kaleta C, Cochemé HM. (2020) Sugar-Induced Obesity and Insulin Resistance Are Uncoupled from Shortened Survival in Drosophila. Cell Metab. 31(4), 710