Meet the team
Benjamin MoyonTransgenic SpecialistMichael Jonathan WalkerTransgenic Research Technician
If you're interested in joining the LMS
The facility provides help to all users internally and externally in the generation of genetically altered murine lines, the rederivation of already existing lines as well as their cryopreservation and storage.
We offer generation of GA animals via:
We offer to rederive lines via:
We will offer to cryopreserve and/or store any lines via:
We hope to generate as many models as necessary for users in order for them to understand better the function of many different genes, how they interact with each other, or how gene dysfunction can lead to disease. To understand normal physiological processes and abnormal disease processes, the use of genetically modified animal models is required, and basic/translational research indispensable.
Roman-Trufero M, Ito CM, Pedebos C, Magdalou I, Wang YF, Karimi MM, Moyon B, Webster Z, di Gregorio A, Azuara V, Khalid S, Speck C, Rodriguez T, Dillon N. (2020). Evolution of an amniote-specific mechanism for modulating ubiquitin signalling via phosphoregulation of the E2 enzyme UBE2D3. Mol Biol Evol. doi: 10.1093/molbev/msaa060
Alfazema N, Barrier M, de Procé SM, Menzies RI, Carter R, Stewart K, Diaz AG, Moyon B, Webster Z, Bellamy COC, Arends ML, Stimson RH, Morton NM, Aitman TJ, Coan PM. (2019). Camk2n1 Is a Negative Regulator of Blood Pressure, Left Ventricular Mass, Insulin Sensitivity, and Promotes Adiposity. Hypertension, 74:687–696.
Salker MS, Singh Y, Durairaj RRP, Yan J, Alauddin M, Zeng N, Steel JH, Zhang S, Nautiyal J, Webster Z, Brucker SY, Wallwiener D, Anne Croy B, Brosens JJ, Lang F (2018) LEFTY2 inhibits endometrial receptivity by downregulating Orai1 expression and store-operated Ca2+entry. J Mol Med. 96(2):173-182. doi: 10.1007/s00109-017-1610-9
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Coan PM, Barrier M, Alfazema N, Carter RN, Marion de Procé S, Dopico XC, Garcia Diaz A, Thomson A, Jackson-Jones LH, Moyon B, Webster Z, Ross D, Moss J, Arends MJ, Morton NM, Aitman TJ (2017) Complement Factor B Is a Determinant of Both Metabolic and Cardiovascular Features of Metabolic Syndrome. Hypertension 70:624–633 doi: 10.1161/HYPERTENSIONAHA.117.09242.
Van de Pette M, Abbas A, Feytout A, McNamara G, Bruno L, To WK, Dimond A, Sardini A, Webster Z, McGinty J, Paul EJ, Ungless MA, French PMW, Withers DJ, Uren A, Ferguson-Smith AC, Merkenschlager M, John RM, Fisher AG. (2017) Visualizing Changes in Cdkn1c Expression Links Early-Life Adversity to Imprint Mis-regulation in Adults. Cell Rep. 18(5):1090-1099. doi: 10.1016/j.celrep.2017.01.010.
Amouroux R, Nashun B, Shirane K, Nakagawa S, Hill PW, D’Souza Z, Nakayama M, Matsuda M, Turp A, NdjeteheE, Encheva V, Kudo NR, Koseki H, Sasaki H, Hajkova P. (2016) De novo DNA methylation drives 5hmC accumulation in mouse zygotes. Nat Cell Biol. 18(2):225-233. doi: 10.1038/ncb3296.
Nashun B, Hill PW, Smallwood SA, Dharmalingam G, Amouroux R, Clark SJ, Sharma V, Ndjetehe E, Pelczar P, Festenstein RJ, Kelsey G, Hajkova P. (2015) Continuous Histone Replacement by Hira Is Essential for Normal Transcriptional Regulation and De Novo DNA Methylation during Mouse Oogenesis. Mol Cell.19;60(4):611-25. doi: 10.1016/j.molcel.2015.10.010.