Meet the team

Metabolism and cell growth research

“What is the link between metabolic disease and cancer?” 

The prevalence of obesity is increasing worldwide, with one in eight people living with obesity in 2022, according to the World Health Organization. Obesity affects our body’s metabolic processes, and can lead to insulin resistance, type 2 diabetes, and cardiovascular diseases.
Obesity is also a risk factor for several types of cancer and a promoter of cancer progression, although the biological mechanisms underlying this link remain incompletely understood.
Our research focuses on investigating these links using the model organism fruit fly Drosophila melanogaster. We aim to use the insights from Drosophila models as a basis for developing future strategies in cancer prevention and treatment.

“We explore complex interactions between metabolic disease and cancer progression”

The prevalence of obesity is increasing worldwide, with one in eight people living with obesity in 2022, according to the World Health Organization. Obesity affects our body’s metabolic processes, and can lead to insulin resistance, type 2 diabetes, and cardiovascular diseases.
Obesity is also a risk factor for several types of cancer and a promoter of cancer progression, although the biological mechanisms underlying this link remain incompletely understood.
Our research focuses on investigating these links using the model organism fruit fly Drosophila melanogaster. We aim to use the insights from Drosophila models as a basis for developing future strategies in cancer prevention and treatment.

Diet-induced obesity promotes tumor overgrowth in Drosophila.

Diet-induced obesity promotes tumor overgrowth in Drosophila. Ras/Src-activated tumors (labeled with GFP; green) in the Drosophila eye epithelial tissues of animals raised on a control diet (left) and a high-sugar diet (right).

Our research is supported by

UKRI Medical Research Council logo

Selected publications

Choutka C, Cabrera C, Hirabayashi S. (2022) Embracing complexity in Drosophila cancer modelsDis Model Mech 15 (3). https://doi.org/10.1242/dmm.049513

Newton H, Wang Y, Camplese L, Mokochinski JB, Kramer HB, Brown AEX, Fets L, Hirabayashi S. (2020). Systemic muscle wasting and coordinated tumour response drive tumourigenesisNature Communications 11, 4653.

Hirabayashi S and Cagan R. (2020). Systemic Regulation of Local Cell CompetitionDevelopmental Cell 53, 371-372.

Hirabayashi S (2016). The interplay between obesity and cancer: a fly viewDis Model Mech 9, 917-926.

Hirabayashi S, Baranski TJ, Cagan RL. (2013). Transformed Drosophila Cells Evade Diet-Mediated Insulin Resistance through Wingless SignalingCell 154, 664-675.

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