The Arlt lab, which focusses on the role of steroid metabolism and action in human disease, moved to the LMS in 2023. Our work explores tissue-specific regulation of steroid action with a focus on the role of androgens in metabolic dysfunction. We are very interested in mechanisms that explain sex differences in the impact of androgens on metabolism.
We work on the role of steroids on human health and disease, with a focus on tissue-specific steroid activation and inactivation. Major focus is the link between androgens and metabolic disease in women and men. We use human-based in vitro, ex vivo and in vivo approaches and steroid mass spectrometry.
Our translational context is Ageing, Cardiometabolic Disease and Multimorbidity. We are specifically looking at the impact of life course and sex differences on human metabolic disease. We would like to achieve progress for conditions that more often or severely affect women, including polycystic ovary syndrome, type 2 diabetes and hypertension.
Our research benefits from several clinical cohort and intervention studies we lead on or participate in. Examples include the DAISy-PCOS cohort study with the European Network for the Study of Adrenal Tumours (ENSAT) and associated EU collaborations including HT-Advance and the international EURINE-ACT study
More updates will be available soon.
Biehl, M., Pavlov, D., Sitch, A.J., Prete, A., Arlt, W. (2024). Interpretable Machine Learning in Endocrinology: A Diagnostic Tool in Primary Aldosteronism. In: Villmann, T., Kaden, M., Geweniger, T., Schleif, FM. (eds) Advances in Self-Organizing Maps, Learning Vector Quantization, Interpretable Machine Learning, and Beyond. WSOM+ 2024. Lecture Notes in Networks and Systems, vol 1087. Springer, Cham. https://doi.org/10.1007/978-3-031-67159-3_11
Thaís Rocha, Eka Melson, Javier Zamora, Borja Manuel Fernandez-Felix, Wiebke Arlt, Shakila Thangaratinam, Sex-Specific Obesity and Cardiometabolic Disease Risks in Low- and Middle-Income Countries: A Meta-Analysis Involving 3 916 276 Individuals, The Journal of Clinical Endocrinology & Metabolism, Volume 109, Issue 4, April 2024, Pages 1145–1153, https://doi.org/10.1210/clinem/dgad599
Sunil Aggarwal, Alessandro Prete, Vasileios Chortis, Miriam Asia, Robert P Sutcliffe, Wiebke Arlt, Cristina L Ronchi, Niki Karavitaki, John Ayuk, Yasir S Elhassan, Pheochromocytomas Most Commonly Present As Adrenal Incidentalomas: A Large Tertiary Center Experience, The Journal of Clinical Endocrinology & Metabolism, Volume 109, Issue 1, January 2024, Pages e389–e396, https://doi.org/10.1210/clinem/dgad401
Iris C M Pelsma, Martin Fassnacht, Stylianos Tsagarakis, Massimo Terzolo, Antoine Tabarin, Anju Sahdev, John Newell-Price, Ljiljana Marina, Kerstin Lorenz, Irina Bancos, Wiebke Arlt, Olaf M Dekkers, Comorbidities in mild autonomous cortisol secretion and the effect of treatment: systematic review and meta-analysis, European Journal of Endocrinology, Volume 189, Issue 4, October 2023, Pages S88–S101, https://doi.org/10.1093/ejendo/lvad134
