Filipe Gomes Cabreiro

About me

Experience:

2018 -

Present

Associate Professor (Reader), Imperial College London

2021 -

Present

Professor, CECAD, University of Cologne, Germany

2017 -

2020

EMBO Young Investigator Programme

2014 -

2021

Wellcome Trust/Royal Society Sir Henry Dale Fellowship, UCL

2013 -

2018

Senior Lecturer, UCL

2008 -

2013

Post-doctoral researcher, UCL

2005 -

2008

PhD Biochemistry, University Paris VII Diderot, France

2004 -

MSc Biology of Ageing, University Paris VII Diderot, France

2003 -

BSc Applied Biochemistry, University of Porto, Portugal

Research focus:

At LMS our main research focus is on understanding the role that the gut microbiota plays in regulating host physiology. In particular, we use a combination of diverse model systems allied to omics approaches to understand more specifically how the microbiota regulates the effects of drugs in cancer and ageing.

Joined LMS:

2018

About me:

I am passionate about biochemistry, microbiology, and pharmacology, driven by a curiosity to understand the molecular mechanisms of life. My interest lies in exploring how biochemical processes shape cellular functions, how microorganisms interact with their environments, and how pharmacological agents influence health and disease. This interdisciplinary focus fuels my desire to contribute to advancements in medicine, where I seek to unravel complex biological systems and develop innovative solutions for therapeutic challenges.

My awards and achievements:

Royal Society/Wellcome Sir Henry Dale
EMBO Young Investigator

Impact of my work:

Our work helps us understand why diverse individuals respond differently to therapy, an important step towards personalised medicine. In addition, our work aims at identifying novel microbial derived compounds that can enhance the effects of therapy in diverse disease contexts.

My Research

Host-microbe co-metabolism

We strive to better understand the role that commensal microbes play in metabolism, disease and ageing and in the efficacy of drugs aimed at treating disease.

VIEW MY RESEARCH GROUP

Selected publications

Essmann CL, Martinez-Martinez D, Pryor R, Leung K-Y,Krishnan KB, Lui PP, Greene NDE, Brown A, Pawar VM, Srinivasan MA, Cabreiro F. (2020). Mechanical properties measured by Atomic Force Microscopy define new health biomarkers in ageing C. elegans. Nature Communications 11 (1), 1-16.

Pryor R, Martinez-Martinez D, Quintaneiro L, and Cabreiro, F. (2020). The Role of the Microbiome in Drug Response. Annual Review of Pharmacology and Toxicology, 60, 417-435.

Rutter JW, Ozdemir T, Galimov ER, Quintaneiro LM, Rosa L, Thomas GM, Cabreiro F and Barnes CP. (2019). Detecting Changes in the Caenorhabditis elegans Intestinal Environment Using an Engineered Bacterial Biosensor. ACS Synthetic Biology 8 (12), 2620-2628.

Bana B and Cabreiro F. (2019). The Microbiome and Aging. Annu Rev Genet 53, 239-261

Pryor R, Norvaisas P, Marinos G, Best L, Thingholm LB, Quintaneiro LM, De Haes W, Esser D, Waschina S, Lujan C, Smith RL, Scott TA, Martinez-Martinez D, Woodward O, Bryson K, Laudes M, Lieb W, Houtkooper RH, Franke A, Temmerman L, Bjedov I, Cochemé HM, Kaleta C, Cabreiro F. (2019). Host-Microbe-Drug-Nutrient screen identifies bacterial effectors of metformin therapy. Cell, 178(6), 1299-1312.

Norvaisas P and Cabreiro F. (2018). Pharmacology in the age of the holobiont. Current Opinion in Systems Biology, 10, 34-42.

Scott TA, Quintaneiro LM, Norvaisas P, Lui PP, Wilson MP, Leung KY, Herrera-Dominguez L, Sudiwala S, Pessia A, Clayton PT, Bryson K, Velagapudi V, Mills PB, Typas A, Greene NDE, Cabreiro F. (2017). Host-Microbe Co-metabolism Dictates Cancer Drug Efficacy in C. elegans. Cell 169, 442-456 e418.

Cabreiro F. (2015). Metformin joins forces with microbes. Cell Host and Microbe, 19(1), 1-3.

Pryor R, Cabreiro F. (2015). Repurposing metformin: an old drug with new tricks in its binding pockets. Biochemical Journal, 471(3), 307-322.

Cabreiro F, Au C, Leung KY, Vergara-Irigaray N, Cochemé HM, Noori T, Weinkove D, Schuster E, Greene ND, Gems D. (2013). Metformin retards aging in C. elegans by altering microbial folate and methionine metabolism. Cell 153, 228-239.

Cabreiro F, Gems D. (2013). Worms need microbes too: microbiota, health and aging in Caenorhabditis elegans. EMBO Mol Med 5, 1300-1310.

Coburn C, Allman E, Mahanti P, Benedetto A, Cabreiro F, Pincus Z, Matthijssens F, Araiz C, Mandel A, Vlachos M, Edwards SA, Fischer G, Davidson A, Pryor RE, Stevens A, Slack FJ, Tavernarakis N, Braeckman BP, Schroeder FC, Nehrke K, Gems D. (2013). Anthranilate fluorescence marks a calcium-propagated necrotic wave that promotes organismal death in C. elegans. PLoS Biol 11, e1001613.

Burnett C*, Valentini S*, Cabreiro F*, Goss M, Somogyvári M, Piper MD, Hoddinott M, Sutphin GL, Leko V, McElwee JJ, Vazquez-Manrique RP, Orfila AM, Ackerman D, Au C, Vinti G, Riesen M, Howard K, Neri C, Bedalov A, Kaeberlein M, Soti C, Partridge L, Gems D. (2011). Absence of effects of Sir2 overexpression on lifespan in C. elegans and Drosophila. Nature 477, 482-485.

* equally contributed.

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