Our laboratory is dedicated to unraveling the intricate mechanisms by which cells organize and manage their extensive DNA molecules. Our primary focus is on understanding the roles of Structural Maintenance of Chromosomes (SMC) complexes and topoisomerases. These essential factors are crucial for the regulation of DNA and chromosomes, impacting a wide range of DNA-centric processes such as transcription, replication, repair, and chromosome segregation. Our ultimate goal is to translate this fundamental knowledge into the development of novel therapeutic strategies targeting these components in various diseases, including cancer and viral infections.