My Research

Redox metabolism

Redox signalling is a critical process within the cell essential for key signalling pathways. We are working to better understand the molecular processes that guide its role in metabolism, disease, and ageing, and to uncover novel pathways and potential therapeutic targets.

VIEW MY RESEARCH GROUP

Selected publications

Lennicke C and Cochemé HM. (2021) Redox metabolism: ROS as specific molecular regulators of cell signaling and function Molecular Cell 81(18) 3691-3707. https://doi.org/10.1016/j.molcel.2021.08.018

Lennicke C and Cochemé HM. (2021) Redox regulation of the insulin signalling pathway. Redox Biology 42, 101964.

van Dam E, van Leeuwen LAG, dos Santos E, James J, Best L, Lennicke C, Vincent AJ, Marinos G, Foley A, Buricova M, Mokochinski JB, Kramer HB, Lieb W, Laudes M, Franke A, Kaleta C and Cochemé HM. (2020). Sugar-induced obesity and insulin resistance are uncoupled from shortened survival in DrosophilaCell Metabolism 31(4), 710-725.

Lennicke C and Cochemé HM. (2020). Redox signalling and ageing: insights from Drosophila. Biochemical Society Transactions 48(2): 367–377.

Cochemé HM*, Bjedov I, Grönke S, Menger KE, James AM, Castillo-Quan JI, Foley A, Lennicke C, Buricova M, Adcott J, Cabreiro F, Murphy MP, Partridge L*. (2019). Enhancing autophagy by redox regulation extends lifespan in Drosophila. BioRxiv 790378. (*co-corresponding)

Pryor R, Norvaisas P, Marinos G, Best L, Thingholm LB, Quintaneiro LM, De Haes W, Esser D, Waschina S, Lujan C, Smith RL, Scott TA, Martinez-Martinez D, Woodward O, Bryson K, Laudes M, Lieb W, Houtkooper RH, Franke A, Temmerman L, Bjedov I, Cochemé HM, Kaleta C, Cabreiro F. (2019). Host-Microbe-Drug-Nutrient Screen Identifies Bacterial Effectors of Metformin Therapy. Cell 178:1299-1312.

van Leeuwen LAG, Hinchy EC, Murphy MP, Robb EL, Cochemé HM. (2017). Click-PEGylation – A mobility shift approach to assess the redox state of cysteines in candidate proteinsFree Radical Biology & Medicine 108, 374-382.

Cochemé HM, Quin C, McQuaker SJ, Cabreiro F, Logan A, Prime TA, Abakumova I, Patel JV, Fearnley IM, James AM, Porteous CM, Smith RA, Saeed S, Carré JE, Singer M, Gems D, Hartley RC, Partridge L, Murphy MP. (2011). Measurement of H2O2 within living Drosophila during aging using a ratiometric mass spectrometry probe targeted to the mitochondrial matrix. Cell Metabolism 13(3), 340–350.

View all Publications