About me
Experience:
Member of the European Molecular Biology Organisation (EMBO)
2008 -
Present
Professor of Genetics, Imperial College London
2007 -
Present
Programme Leader (MRC LMS)
2002 -
2007
Programme Leader Track (MRC LMS)
2001 -
2002
Lecturer (Queen Mary University of London, UK)
1999 -
2001
Postdoctoral Fellow (NIH, USA)
2000 -
1997 -
Research focus:
The research of my group is focused on uncovering the mechanisms, regulation, and function of the three eukaryotic SMC complexes: cohesin, condensin, and Smc5/6. In addition, we also study how Topoisomerases complement SMC complexes enabling critical functions during DNA replication and repair, as well as chromosome segregation. Employing both in vitro and in vivo approaches, our research aims to understand SMC and Topoisomerase mechanisms and explore strategies to target these complexes with clinically relevant drugs.
About me:
I joined the LMS attracted by its core funding, exclusive research focus and support of discovery science with implications for disease. These aspects perfectly matched my goal of addressing questions that required long-term research support and innovation.
My awards and achievements:
EMBO Member
Impact of my work:
Research on human SMC complexes holds promise for medical advances, drug development, and therapeutic applications. Insights into SMC function may lead to targeted therapies for genetic disorders and cancers. Understanding SMC complex mechanisms can also impact biotechnology and provide critical knowledge of fundamental cellular processes.