£41,344 plus London allowances £5,385 per annum*
Project Title: Novel immunotherapies to target senescence-associated diseases
About us
Our lab has contributed to understanding the role of senescence as a tumour suppressor mechanism (Collado et al. Nature 2005), in limiting iPSC reprogramming (Banito et al. Genes Dev 2009) or activating immune surveillance (Kang et al. Nature 2011). We have also identified molecular mechanisms controlling senescence (Gil et al. Nat Cell Biol 2004; Tordella et al. Genes Dev 2016), the inflammatory phenotype associated with senescence (Acosta et al. Cell 2008; Acosta et al. Nat Cell Biol 2013; Herranz et al. Nat Cell Biol 2015; Georgilis et al. Cancer Cell 2018) ,how to target senescent cells (Guerrero et al. Nat Metabolism 2019; Guerrero et al. Nat Aging 2022; McHugh et al. Nat Cell Biol 2023) and the relationship between senescence and immune cells (Haston et al. Cancer Cell 2023; Reen et al. Sci Adv 2025).
About you
The successful candidate will work on a project collaborating with MiNK Therapeutics and Agenus Bio to identify novel strategies to potentiate immune-mediated elimination of senescent cells. You should be highly motivated, committed and have clear career goals. Experience with animal work, immunology and studying immune-mediated elimination of tumours is essential. Working with viral vectors, functional screenings, and 3D cultures is desirable. All applicants should have a PhD degree in life sciences or equivalent experience, and at least one first-author primary publication published. Availability to start working as soon as possible is essential. A Home Office Personal License is desirable.
What we offer
As well as the exciting opportunities this role presents, we also offer defined benefit pension scheme and excellent holiday entitlement (30 days plus 2.5 privilege days & 8 bank holidays), family friendly policies (6 months full pay maternity & adoption leave), a range of shopping/travel discounts, access to our Employee Assistant Programme Scheme, Health and Wellbeing Support and a salary sacrifice cycle to work scheme: Benefits
How to apply
For full details of this post and to complete an online application, visit MRC Postdoctoral Research Scientist LMS 2614 – Medical Research Council and upload your CV, names and contacts of two scientific references along with a cover letter stating why you are applying for this role (providing evidence against the requirements of the job as per the job description and person specification). Applications without a cover letter will not be accepted. Please quote reference number LMS 2614.
*Additional allowances comprise a £1,000 lump sum Settlement Allowance plus a yearly Training Allowance of £850 in the first year, paid in monthly instalments. The Training Allowance increases to £1,300 in year two which will be adjusted accordingly.
Closing date: 1 June 2025
The final appointment will be subject to pre-employment screening
Please note that applications may be reviewed by both LMS and Imperial staff
Athena SWAN
In 2017, the Institute received an Athena SWAN Silver Award to recognize its commitment to advancing women’s careers in science and research.
At the LMS there are three working groups which deliver on the action plan developed for the silver application.
Equality, diversity and wellbeing
The MRC LMS is committed to creating equality of opportunity to all members of the organisation, regardless of their background, and promoting diversity and inclusivity. We observe the Medical Research Council’s Equality and Diversity Vision, which sets out the MRC’s commitment to fulfill its obligations as a public body under the Equality Act 2010.
Technician’s Commitment
The LMS is a signatory to the Technician Commitment, a sector-wide initiative led by the Science Council and the Gatsby Foundation which aims to address the particular career challenges faced by technical and scientific support staff.
We provide opportunities to work alongside some of the top medical researchers on the planet, from our state-of-the-art research facilities.