Salary: £42,694 per annum plus London allowance £5,560 per annum*
*Additional allowances comprise a £1,000 lump sum Settlement Allowance plus a yearly Training Allowance of £850 in the first year, paid in monthly instalments. The Training Allowance increases to £1,300 in year two and £1,800 in year three.
Team Science
Scientific breakthroughs rarely come from isolation—they emerge when brilliant minds connect. Our Team Science approach is more than just multi-disciplinary; it’s a fundamentally different way of working. We foster deep collaboration across fields, institutions, industry, and society to tackle questions that no one could answer alone. As a postdoc, you’ll be part of a dynamic environment that values your individual expertise while amplifying it through shared infrastructure, collective ambition, and interdisciplinary innovation.
About the roles
Applicants are encouraged to review all 6 positions and apply to the one that best aligns with their expertise and research interests. In your cover letter, please clearly indicate which position you are applying for:
Purpose of Postdoctoral Post (Role 1) LMS 2729
This Postdoctoral Researcher position investigates how nucleic acid-sensing pathways (such as cGAS/STING, RIG-I, and MDA5) affect cellular senescence and the crucial interaction between senescent and immune cells. The role requires integrating expertise in the culture of primary cells and organoids with knowledge of molecular biology, immunology, and functional screens. The successful candidate will develop and apply sophisticated functional genomic assays and co-culture systems to evaluate these processes in the context of ageing.
Purpose of Postdoctoral Post (Role 2) LMS 2730
This Postdoctoral Researcher will use optical tweezers combined with fluorescence imaging for real-time, quantitative visualisation of nucleic acid sensors (cGAS, AIM2, RIG-I, etc.). The goal is to directly observe how these sensors interact with DNA and RNA substrates under applied force, revealing how their function is modulated by nucleic acid structure and post-translational modifications. A key part of this role involves leading the design of biochemical assays for high-throughput drug screening. In collaboration with the Imperial Drug Discovery Hub, you will identify and validate inhibitors or activators of key nucleic acid sensors.
Purpose of Postdoctoral Post (Role 3) LMS 2731
This Postdoctoral Researcher focuses on computational analysis and the integration of single-cell and spatial multiomic datasets. The project aims to unravel the effects of nucleic acid-sensing pathways on tissue ageing, inflammation, and senescence. The postholder will apply a range of computational approaches and work collaboratively with participating groups to analyse the specific involvement of human genetic variants, gene regulatory networks, and molecular ‘ageing’ clocks.
Purpose of Postdoctoral Post (Role 4) LMS 2732
This Postdoctoral Scientist role requires a strong interest and expertise in various -omics approaches (including spatial transcriptomics) and a passion for reproductive biology. The main goal of this project is to investigate the molecular causes of infertility and the effect of the environment on germline development. This will be accomplished using both in vivo models (mouse tissues and human samples) and in vitro models, such as mouse and human pluripotent stem cell-derived primordial germ cell like cells (PGClCs).
Purpose of Postdoctoral Post (Role 5) LMS 2733
This Computational Biologist position focuses on reproductive biology and genome function. The main goal of the project is to analyse and integrate multimodal genome-wide datasets to build predictive models of healthy reproductive processes. The researcher will also investigate how these processes are perturbed in the context of infertility and ageing.
Purpose of Postdoctoral Post (Role 6) LMS 2734
This Chromosome Biology Specialist position joins the team science initiative to investigate sex-specific differences in meiotic chromosome organisation and function. This research will be conducted across different organisms (C. elegans, mouse, and human samples) using state-of-the-art experimental approaches, including super-resolution microscopy, proteomics, and 3D genome conformation studies.
What we offer
As well as the exciting opportunities this role presents, we also offer defined benefit pension scheme and excellent holiday entitlement (30 days plus 2.5 privilege days & 8 bank holidays), family friendly policies (6 months full pay maternity & adoption leave), a range of shopping/travel discounts, access to our Employee Assistant Programme Scheme, Health and Wellbeing Support and a salary sacrifice cycle to work scheme. Please follow this link to find out more – Benefits
How to apply
For full details of these posts and to complete an online application, visit the posts below
and upload your CV, names and contacts of two scientific references, along with a cover letter stating why you are applying for this role (providing evidence against the requirements of the job as per the job description and person specification). Applications without a cover letter will not be accepted.
Closing date: 31 December 2025
Applicants are encouraged to review the brochure for additional information and positions in the Team Science project.
Please note that applications may be reviewed by both LMS and Imperial staff
Athena SWAN
In 2017, the Institute received an Athena SWAN Silver Award to recognize its commitment to advancing women’s careers in science and research.
At the LMS there are three working groups which deliver on the action plan developed for the silver application.
Equality, diversity and wellbeing
The MRC LMS is committed to creating equality of opportunity to all members of the organisation, regardless of their background, and promoting diversity and inclusivity. We observe the Medical Research Council’s Equality and Diversity Vision, which sets out the MRC’s commitment to fulfill its obligations as a public body under the Equality Act 2010.
Technician’s Commitment
The LMS is a signatory to the Technician Commitment, a sector-wide initiative led by the Science Council and the Gatsby Foundation which aims to address the particular career challenges faced by technical and scientific support staff.
We provide opportunities to work alongside some of the top medical researchers on the planet, from our state-of-the-art research facilities.