Michelle Percharde

About me

Experience:

2023 -

2026

UKRI Future Leaders Fellowship Renewal (MRC LMS)

2021 -

Present

Programme Leader Track (MRC LMS) Maternity Leave Oct 2022-April 2023

2019 -

2023

UKRI Future Leaders Fellowship (MRC LMS) Maternity Leave May 2020-Nov 2020

2014 -

2017

California Institute of Regenerative Medicine (CIRM) Postdoctoral Fellowship

2013 -

2018

Postdoctoral Research Fellow, University of California at San Francisco (UCSF), CA, USA

2008 -

2013

PhD Reproductive and Developmental Biology (Imperial College London)

2007 -

2008

Research Assistant (Institute of Cancer Research (ICR), London, UK)

2004 -

2007

BA Natural Sciences (University of Cambridge, UK)

Joined LMS:

2019

About me:

Michelle is an epigenetics and stem cell biologist. She carried out her undergraduate degree in Biochemistry at the University of Cambridge and PhD in reprogramming and nuclear receptors at Imperial College, London. In 2013, she moved to UCSF and was awarded a CIRM postdoctoral fellowship to carry out her postdoctoral training with Prof. Miguel Ramalho-Santos. She moved to Imperial College and the MRC London Institute of Medical Sciences (LMS) and in May 2019 started the Chromatin & Development Group, funded by one of the first ever UKRI Future Leaders Fellowships. She has two young children, born after she started her lab at the LMS.

Key hobbies outside of work (when family permits) involve biking, trying to create furniture with her husband, scuba diving and baking.

My Research

Chromatin and development

Our lab is interested in the transcriptional and epigenetic regulation of early development. We study how transposons have been co-opted to regulate essential processes in development, and how their misregulation may contribute to disease.

VIEW MY RESEARCH GROUP

Selected publications

De Souza, R. A., Barneda, D., Karimlou, D., Bovee, N. G., Zheng, Y., Kahlman, E. J., Novo, C. L., Ellis, J. K., Leeke, B. J., Bangalore, M. P., Liu, Z., Sousa, B. C., Lopez-Clavijo, A. F., Jansen, J. H., Barahona, M., Percharde, M., Keun, H. C., Christian, M., Marks, H., & Azuara, V. (2024). The exit of naïve pluripotency contains a lipid metabolism-induced checkpoint for genome integrity. bioRxiv (Cold Spring Harbor Laboratory). https://doi.org/10.1101/2024.09.22.613751

Mau, K.H.T., Karimlou, D., Barneda, D., Brochard V., Royer C., Leeke B., A de Souza R., Pailles M., Percharde M., Srinivas S., Jouneau A., Christian M., Azuara V. (2022) Dynamic enlargement and mobilization of lipid droplets in pluripotent cells coordinate morphogenesis during mouse peri-implantation development. Nat Commun 13, 3861. https://doi.org/10.1038/s41467-022-31323-2

Xie SQ, Leeke BJ, Whilding C, Wagner RT, Garcia-Llagostera F, Low XY, Chammas P, Cheung NT-F, Dormann D, McManus MT, Percharde M. (2022) Nucleolar-based Dux repression is essential for embryonic two-cell stage exit. Genes Dev, Mar 10. doi: 10.1101/gad.349172.121

Percharde M, Sultana T & Ramalho-Santos M. (2020). What Doesn’t Kill You Makes You Stronger: Transposons as Dual Players in Chromatin Regulation and Genomic Variation. Bioessays; 42, 4.

Lu JY, Shao W, Chang L, Yin Y, Li T, Zhang H, Hong Y, Percharde M, Guo L, Wu Z, Liu L, Liu W, Yan P, Ramalho-Santos M, Sun Y, Shen X. (2020). Genomic Repeats Categorize Genes With Distinct Functions for Orchestrated Regulation. Cell Reports,10;30(10):3296-3311.e5

DiTroia SP, Percharde M, Guerquin M, Wall E, Collignon E, Ebata KT, Mesh K, Mahesula S, Agathocleous M, Laird DJ, Livera G, Ramalho-Santos M. (2019). Maternal vitamin C regulates reprogramming of DNA methylation and germline development. Nature. 573, 271-275.

Percharde M, Lin C-J, Yin Y, Guan J, Peixoto GA, Bulut-Karslioglu A, Biechele S, Huang B, Shen X, Ramalho-Santos M. (2018). A LINE1-Nucleolin Partnership Regulates Early Development and ESC Identity. Cell. 174, 391-405.

Bulut-Karslioglu A, Macrae TA, Oses-Prieto JA, Covarrubias S, Percharde M, Ku G, Diaz A, McManus MT, Burlingame AL, Ramalho-Santos M. (2018). The Transcriptionally Permissive Chromatin State of Embryonic Stem Cells Is Acutely Tuned to Translational Output. Cell Stem Cell. 22, 369-383

Percharde M, Wong P, Ramalho-Santos M. (2017). Global Hypertranscription in the Mouse Embryonic Germline. Cell Reports. 19, 1987-1996.

Percharde M, Bulut-Karslioglu A, Ramalho-Santos M. (2017). Hypertranscription in Development, Stem Cells, and Regeneration. Developmental Cell. 40, 9-21.

Qin H, Hejna M, Liu Y, Percharde M, Wossidlo M, Blouin L, Durruthy-Durruthy J, Wong P, Qi Z, Yu J, Qi LS, Sebastiano V, Song JS, Ramalho-Santos M. (2016). YAP Induces Human Naive Pluripotency. Cell Reports. 14, 2301-2312.

Percharde M, Lavial F, Ng J-H, Kumar V, Tomaz RA, Martin N, Yeo J-C, Gil J, Prabhakar S, Ng H-H, Parker MG, Azuara V. (2012). Ncoa3 functions as an essential Esrrb coactivator to sustain embryonic stem cell self-renewal and reprogramming. Genes & Development. 26, 2286-2298.

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