Our research focuses on the molecular mechanisms underlying mental illnesses. We aim to identify new targets for drug development and biomarkers to improve patient care.
McCutcheon RA, Brown K, Nour MM, Smith SM, Veronese M, Zelaya F, Osugo M, Jauhar S, Hallett W, Mehta MM, Howes OD. (2021). Dopaminergic organization of striatum is linked to cortical activity and brain expression of genes associated with psychiatric illness. SCIENCE Adv. 7(24):eabg1512. doi: 10.1126/sciadv.abg1512
Veronese M, Santangelo B, Jauhar S, D’Ambrosio E, Demjaha A, Salimbeni H, Huajie J, McCrone P, Turkheimer F, Howes O. (2021). A potential biomarker for treatment stratification in psychosis: evaluation of an [18F] FDOPA PET imaging approach. Neuropsychopharmacology. 46(6):1122-1132. doi: 10.1038/s41386-020-00866-7
Onwordi EC, Halff EF, Whitehurst T, Mansur A, Cotel MC, Wells L, Creeney H, Bonsall D, Rogdaki M, Shatalina E, Reis Marques T, Rabiner EA, Gunn RN, Natesan S, Vernon AC, Howes OD. (2020).Synaptic density marker SV2A is reduced in schizophrenia patients and unaffected by antipsychotics in rats. NATURE Commun. 11(1):246. doi: 10.1038/s41467-019-14122-0
Borgan F, O’Daly O, Hoang K, Veronese M, Withers D, Batterham R, Howes O. (2019). Neural Responsivity to Food Cues in Patients With Unmedicated First-Episode Psychosis. JAMA Netw Open, DOI: 10.1001/jamanetworkopen.2018.6893.
Nour MM, Dahoun T, Schwartenbeck P, Adams RA, FitzGerald THB, Coello C, Wall MB, DOlan RJ, Howes OD. (2018). Dopaminergic basis for signaling belief updates, but not surprise, and the link to paranoia. Proceeding of the National Academy of Science of the United States of America, 115(43), 10167-10176.
Bloomfield PS, Bonsall D, Wells L, Dormann D, Howes O, De Paola V. (2018). The effects of haloperidol on microglial morphology and translocator protein levels: An in vivo study in rats using an automated cell evaluation pipeline. J Psychopharmacol. 32(11):1264-1272.
Dahoun T, Pardiñas AF, Veronese M, Bloomfield MAP, Jauhar S, Bonoldi I, Froudist-Walsh S, Nosarti C, Korth C, Hennah W, Walters J, Prata D, Howes OD. (2018). The effect of the DISC1 Ser704Cys polymorphism on striatal dopamine synthesis capacity: an [18F]-DOPA PET study. Hum Mol Genet, 27(20):3498-3506.
Selvaraj S, Walker C, Arnone D, Cao B, Faulkner P, Cowen PJ, Roiser JP, Howes OD (2018). Effect of Citalopram on Emotion Processing in Humans: A Combined 5-HT1A [11C]CUMI-101 PET and Functional MRI Study. Neuropsychopharmacology doi: 10.1038/npp.2017.166.
Pillinger T, Beck K, Gobjila C, Donocik JG, Jauhar S, Howes OD. (2017). Impaired Glucose Homeostasis in First-Episode Schizophrenia: A Systematic Review and Meta-analysis. JAMA Psychiatry, 74(2):261-269.
Jauhar S, Nour MM, Veronese M, Rogdaki M, Bonoldi I, Azis M, Turkheimer F, McGuire P, Young AH, Howes OD. (2017). A Test of the Transdiagnostic Dopamine Hypothesis of Psychosis Using Positron Emission Tomographic Imaging in Bipolar Affective Disorder and Schizophrenia. JAMA Psychiatry 74(12), 1206-1213.
Jauhar S, Veronese M, Rogdaki M, Bloomfield M, Natesan S, Turkheimer F, Kapur S, Howes OD. (2017). Regulation of dopaminergic function: an [18F]-DOPA PET apomorphine challenge study in humans. Transl Psychiatry 7(2):e1027.
Howes OD, McCutcheon R, Owen MJ, Murray RM. (2017). The Role of Genes, Stress, and Dopamine in the Development of Schizophrenia. Biol Psychiatry 81(1), 9-20.
Bloomfield MA, Ashok AH, Volkow ND, Howes OD. (2016). The effects of Δ9-tetrahydrocannabinol on the dopamine system. Nature 17, 539(7629), 369-377.
Bloomfield PS, Selvaraj S, Veronese M, Rizzo G, Bertoldo A, Owen DR, Bloomfield MA, Bonoldi I, Kalk N, Turkheimer F, McGuire P, de Paola V, Howes OD. (2016). Microglial Activity in People at Ultra High Risk of Psychosis and in Schizophrenia: An [(11)C]PBR28 PET Brain Imaging Study. Am J Psychiatry 173(1), 44-52.
Selvaraj S, Mouchlianitis E, Faulkner P, Turkheimer F, Cowen PJ, Roiser JP, Howes O. (2015). Presynaptic Serotoninergic Regulation of Emotional Processing: A Multimodal Brain Imaging Study. Biol Psychiatry, 78(8):563-571.
Howes OD, Murray RM. (2014). Schizophrenia: an integrated sociodevelopmental-cognitive model. Lancet 383(9929), 1677–1687.
Stokes PR, Shotbolt P, Mehta MA, Turkheimer E, Benecke A, Copeland C, Turkheimer FE, Lingford-Hughes AR, Howes OD. (2013). Nature or nurture? determining the heritability of human striatal dopamine function: an [18F]-DOPA PET study. Neuropsychopharmacology 38(3), 485–491.
Selvaraj S, Turkheimer F, Rosso L, Faulkner P, Mouchlianitis E, Roiser JP, McGuire P, Cowen PJ, Howes O. (2012). Measuring endogenous changes in serotonergic neurotransmission in humans: a [11C]CUMI-101 PET challenge study. Molecular Psychiatry 17(12), 1254–1260.
