Research Support

Research Support

Modern research is complex. New technologies and continuing advances in instrumentation mean that research groups generate more data than ever before. The bioinformatics facility works with researchers across the LMS to analyse and interpret experimental data, allowing the varied research of the institute to continue at pace.

Our staff have experience across both bulk and single-cell applications of genomics, transcriptomics, and epigenetics. The group is pleased to provide both ‘hands-off’ analysis services and ‘hands-on’ support, offering advice and practical assistance to those processing and analysing their own data. Additionally, we offer practical training courses in bioinformatics, computing, and statistics throughout the year.

Working closely with the IT facility, the bioinformatics facility supports High Performance Computing (HPC) within the LMS, maintaining the Jex HPC cluster and serving as a point of contact and reference for researchers utilising the provision. Supporting staff to use the available resources, we can assist in the specification and development of programs and pipelines to fulfil research needs.

Services

Services

  • Bioinformatics analysis
  • Support and advice
  • Statistics
  • Training
  • Software design
  • High Performance Computing

Team

Team

Our team is comprised of skilled bioinformaticians from a range of scientific backgrounds. Together, we have extensive experience across bioinformatics and data science, programming, and applications development. Bridging the gap between the wet- and dry-lab, the facility includes experienced biologists who can assist in the design of genomics and molecular biology experiments and with their statistical analysis.

Meet the team

This facility is available to LMS staff and students. Please contact us for availability and support with experimental design.

Enquiries:

Selected publications

Huang TC, Wang YF, Vazquez-Ferrer E, Theofel I, Requena CE, Hanna CW, Kelsey G, Hajkova P. Sex-specific chromatin remodelling safeguards transcription in germ cellsNature. 2021 Dec;600(7890):737-742. doi: 10.1038/s41586-021-04208-5. Epub 2021 Dec 8. PMID: 34880491.

Karimi MM, Guo Y, Cui XPallikonda HA, Horková V, Wang YF, Gil SR, Rodriguez-Esteban G, Robles-Rebollo I, Bruno L, Georgieva R, Patel B, Elliott J, Dore MH, Dauphars D, Krangel MS, Lenhard B, Heyn H, Fisher AG, Štěpánek O, Merkenschlager M. The order and logic of CD4 versus CD8 lineage choice and differentiation in mouse thymus. Nat Commun. 2021 Jan 4;12(1):99. doi: 10.1038/s41467-020-20306-w. PMID: 33397934; PMCID: PMC7782583.

Weiss FD, Calderon L, Wang YF, Georgieva R, Guo Y, Cvetesic N, Kaur M, Dharmalingam G, Krantz ID, Lenhard B, Fisher AG, Merkenschlager M. Neuronal genes deregulated in Cornelia de Lange Syndrome respond to removal and re-expression of cohesinNat Commun. 2021 May 18;12(1):2919. doi: 10.1038/s41467-021-23141-9. PMID: 34006846.

Hudry B, Khadayate S, Miguel-Aliaga I. The sexual identity of adult intestinal stem cells controls organ size and plasticityNature. 2016 Feb 18;530(7590):344-8. doi: 10.1038/nature16953. PMID: 26887495; PMCID: PMC4800002.