Research support

Research support

Modern research is complex. New technologies and continuing advances in instrumentation mean that research groups generate more data than ever before. The bioinformatics facility works with researchers across the LMS to analyse and interpret experimental data, allowing the varied research of the institute to continue at pace.

Our staff have experience across both bulk and single-cell applications of genomics, transcriptomics, and epigenetics. The group is pleased to provide both ‘hands-off’ analysis services and ‘hands-on’ support, offering advice and practical assistance to those processing and analysing their own data. Additionally, we offer practical training courses in bioinformatics, computing, and statistics throughout the year.

Working closely with the IT facility, the bioinformatics facility supports High Performance Computing (HPC) within the LMS, maintaining the Jex HPC cluster and serving as a point of contact and reference for researchers utilising the provision. Supporting staff to use the available resources, we can assist in the specification and development of programs and pipelines to fulfil research needs.

Services

Capabilities

  • Bioinformatics analysis
  • Support and advice
  • Statistics
  • Training
  • Software design
  • High Performance Computing

Team

Team

Our team is comprised of skilled bioinformaticians from a range of scientific backgrounds. Together, we have extensive experience across bioinformatics and data science, programming, and applications development. Bridging the gap between the wet- and dry-lab, the facility includes experienced biologists who can assist in the design of genomics and molecular biology experiments and with their statistical analysis.

Meet the team

Selected publications

Urtasun-Elizari J, Ma R, Pickford H, Farrell D, Perets V, Urtasun-Elizari J, Gonzalez G, Nakajima C, Suzuki Y, Bhatt A, MacHugh DE, Gordon S. (2026) Different transcriptional regulatory activities of Mycobacterium bovis and Mycobacterium tuberculosis PhoPR systemsAccess Microbiology 8:1

Chammas P, Xie SQ, Sepulveda-Rincon LP, Leeke BJ, Dore MH, Dormann D, Wagner RT, Chang N, Jones PL, McManus MT, Karimi MM, Young G, Percharde M. (2025) CRISPRa-mediated disentanglement of the Dux-MERVL axis in the 2C-like state, totipotency, and cell death. Sci Adv. 19;11(51)

Reen V, D’Ambrosio M, Søgaard PP, Tyson K, Leeke BJ, Clément I, Dye ICA, Pombo J, Kuba A, Lan Y, Burr J, Bomann IC, Kalyva M, Birch J, Khadayate S, Young G, Provencher D, Mes-Masson AM, Vernia S, McGranahan N, Brady HJM, Rodier F, Nativio R, Percharde M, McNeish IA, Gil J. (2025) SMARCA4 regulates the NK-mediated killing of senescent cells. Sci Adv. 11(3):eadn2811

Buenaventura T, Bagci H, Patrascan I, Graham JJ, Hipwell KD, Oldenkamp R, King JWD, Urtasun J, Young G, Mouzo D, Gomez-Cabrero D, Rowland BD, Panne D, Fisher AG, Merkenschlager M. (2024) Competition shapes the landscape of X-chromosome-linked genetic diversity. Nat Genet. 56(8):1678-1688

Gallage S, Irvine EE, Barragan Avila JE, Reen V, Pedroni SMA, Duran I, Ranvir V, Khadayate S, Pombo J, Brookes S, Heide D, Dharmalingham G, Choudhury AI, Singh I, Herranz N, Vernia S, Heikenwalder M, Gil J, Withers DJ. (2024) Ribosomal S6 kinase 1 regulates inflammaging via the senescence secretome. Nat Aging. 4(11):1544-1561

Reuter LM, Khadayate SP, Mossler A, Liebl K, Faull SV, Karimi MM, Speck C. (2024) MCM2-7 loading-dependent ORC release ensures genome-wide origin licensing. Nat Commun. 15(1):7306

McGlone ER, Hope DCD, Davies I, Dore M, Goldin R, Jones B, Liu Z, Li JV, Vorkas PA, Khoo B, Carling D, Minnion J, Bloom SR, Tan TM. (2024) Chronic treatment with glucagon-like peptide-1 and glucagon receptor co-agonist causes weight loss-independent improvements in hepatic steatosis in mice with diet-induced obesity. Biomed Pharmacother. 176:116888