“The facility provides state of the art light microscopy equipment and image analysis tools as well as training and support for all LMS users.”

The Microscopy Laboratory offers a large variety of systems ranging from basic stereo microscopes to the latest confocal workstations to assist LMS staff and students in their research.

The facility is currently equipped with four confocal laser scanning microscopes, six widefield fluorescence microscopes and a PALM laser microdissection system. Live-cell imaging is performed on two dedicated workstations enclosed by environmental chambers to maintain constant temperature and CO2 levels. Several offline workstations can be used for image processing, visualisation and analysis of user data. A transmission electron microscope is also available in a separate laboratory.

Staff provide user training and continuing support ranging from help with experimental design, image processing/visualisation and quantitative image analysis to direct collaboration on specific projects.

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Microscopy Facility

Figure 1. Liver section stained with DAPI and TRITC phalloidin

Microscopy Facility

Figure 2. Two mouse fibroblast cell lines expressing H2B-EGFP or H2B-mCherry

Selected Publications

Linneweber, G.A., Jacobson, J., Busch, K.E., Hudry, B., Christov, C.P., Dormann, D., Yuan, M., Otani, T., Knust, E., de Bono, M., Miguel-Aliaga, I. (2014). Neuronal control of metabolism through nutrient-dependent modulation of tracheal branching. Cell, 16, 156(1-2), 69-83.

Frontini, M., Kukalev, A., Leo, E., Ng, Y. M. M., Cervantes, M., Cheng, C. W. W., Holic, R., Dormann, D., Tse, E., Pommier, Y., & Yu, V. (2012). The CDK subunit CKS2 counteracts CKS1 to control cyclin A/CDK2 activity in maintaining replicative fidelity and neurodevelopment. Developmental Cell, 23 (2), 356-370.