Genomics of Obesity


Will Scott

A principal goal of our research is to investigate the mechanisms underlying human obesity and diabetes. We use high-throughput genomics to identify genetic, epigenetic and transcriptomic changes linked to human obesity and diabetes, and advanced genome-editing tools to assign causation to these changes. Adipose tissue cell-types are a main focus of our work because of their key roles in obesity and diabetes pathogenesis. We think that the discovery of key aetiological and pathophysiological mechanisms in adipose tissue will provide us with molecular targets for the development of new therapeutics.