About me

Experience:

2020 -

2026

Wellcome Trust Sir Henry Dale Fellowship (Imperial College London and MRC LMS)

2014 -

2020

Postdoctoral Research Fellow (Francis Crick Institute)

2012 -

2013

Postdoctoral Research Fellow (Institute for Molecular Bioscience, Brisbane, Australia.)

2008 -

2012

PhD Developmental Biology (University of Queensland, Brisbane, Australia)

2006 -

2007

Research Assistant (Institute for Molecular Bioscience, Brisbane, Australia)

2004 -

 

BSc (Hons) Class I Developmental Biology (University of Queensland, Brisbane, Australia)

2002 -

2004

BSc Genetics & Molecular Cell Biology (University of Queensland, Brisbane, Australia)

Research focus:

We wish to understand how the body plan is put together during development. How do we make the right cell type, at the right position, and in the right proportion? These principles underpin healthy development, and inform fields such as regenerative medicine. To address these important questions, we study how cells control their identity and the role of non-coding DNA elements (such as enhancers) in this process.

Joined LMS:

2020

About me:

I am a developmental biologist. I joined the LMS excited by the emphasis on ambitious, field-defining discovery science that extends across multiple disciplines. In every area of the LMS, you'll find outstanding people following their passion with excitement, curiosity, and a drive to do their best possible work. It's highly motivating to work in such an environment.I chair the Athena Swan Careers and Development Working Group at the LMS, and co-chair the 3Rs advisory group at Imperial College London. In 2023, I was elected to the British Society for Developmental Biology (BSDB) committee.

My awards and achievements:

Sir Henry Dale Fellow (awarded 2020 by Wellcome); Sammy Lee Medal (awarded 2017 by Young Embryologist Network)

Impact of my work:

We have updated textbook views on how the nervous system is regionalised during development (Metzis et al., 2018; PMID: 30343898; Needham & Metzis 2022 PMID: 35257719). We have identified regulatory mechanisms that establish cell types in the posterior body (Amblard et al., BioRxiv 2024; Blassberg et al., 2022 PMID: 35550614; Exelby et al., 2021 PMID: 33547135) and during human spinal cord development (Semprich et al., 2022 PMID: 36455041).

My Research

Development and transcriptional control

Our research aims to understand the molecular basis of cell identity, and the transcriptional control mechanisms that determine diversity in cell fate choice during embryonic development.

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Selected publications

Amblard I, Baranasic D, Moyon B, Lenhard B, & Metzis, V. (2024). A dual enhancer-silencer element ensures transientCdx2expression during posterior body formation. bioRxiv (Cold Spring Harbor Laboratory). doi:10.1101/2024.04.10.588878

Needham J, Metzis V. (2022) Heads or tails: making the spinal cord. Dev Biol. 485:80-92. doi: 10.1016/j.ydbio.2022.03.002

Blassberg R, Patel H, Watson T, Gouti M, Metzis V, Delás MJ, Briscoe J. Sox2 levels regulate the chromatin occupancy of WNT mediators in epiblast progenitors responsible for vertebrate body formation. Nat Cell Biol. 2022;24(5):633-644. doi: 10.1038/s41556-022-00910-2

Binagui-Casas A, Dias A, Guillot C, Metzis V, Saunders D. Building consensus in neuromesodermal research: Current advances and future biomedical perspectives. Curr Opin Cell Biol. 2021;73:133-140. doi: 10.1016/j.ceb.2021.08.003

Exelby K, Herrera-Delgado E, Garcia Perez L, Perez-Carrasco R, Sagner A, Metzis V, Sollich P, Briscoe J. (2021) Precision of Tissue Patterning is Controlled by Dynamical Properties of Gene Regulatory NetworksDevelopment 148 (4): dev197566.

Metzis V, Steinhauser S, Pakanavicius E, Gouti M, Stamataki D, Ivanovitch K, Watson T, Rayon T, Mousavy Gharavy SN, Lovell-Badge R, Luscombe NM, Briscoe J. (2018). Nervous System Regionalization Entails Axial Allocation before Neural DifferentiationCell;175(4):1105-1118.e17

Gabrysova L, Alvarez-Martinez M, Luisier R, Cox LS, Sodenkamp J, Hosking C, Perez-Mazliah D, Whicher C, Kannan Y, Potempa K, Wu X, Bhaw L, Wende H, Sieweke MH, Elgar G, Wilson M, Briscoe J, Metzis V, et al. (2018). c-Maf controls immune responses by regulating disease-specific gene networks and repressing IL-2 in CD4(+) T cellsNature Immunology;19(5):497-507.

Lu H, Galeano MCR, Ott E, Kaeslin G, Kausalya PJ, Kramer C, Ortiz-Bruchle N, Hilger N, Metzis V, Hiersche M, et al. (2017). Mutations in DZIP1L, which encodes a ciliary-transition-zone protein, cause autosomal recessive polycystic kidney diseaseNature Genetics;49(7):1025-1034

Gouti M, Metzis V, Briscoe J. (2015). The route to spinal cord cell types: a tale of signals and switchesTrends Genet;31(6):282-9.

Metzis V, Courtney AD, Kerr MC, Ferguson C, Rondon Galeano MC, Parton RG, Wainwright BJ, Wicking C. (2013). Patched1 is required in neural crest cells for the prevention of orofacial cleftsHuman Molecular Genetics;22:5026-5035

Butterfield NC, Metzis V, McGlinn E, Bruce SJ, Wainwright BJ, Wicking C. (2009). Patched 1 is a crucial determinant of asymmetry and digit number in the vertebrate limbDevelopment;136: 3515-3524

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