We use computational and experimental approaches to establish how the workings of the cell condition the evolutionary process. Our goal is to understand how what is happening inside the cell biases the incidence of mutations, affects their persistence, and, ultimately, shapes patterns of natural variation within and between species.
Hocher A, Rojec M, Swadling JB, Esin A, Warnecke T. (2019). The DNA-binding protein HTa from Thermoplasma acidophilum is an archaeal histone analog. eLife, e52542
Rojec M, Hocher A, Stevens KM, Merkenschlager M, Warnecke T. (2019). Chromatinization of Escherichia coli with archaeal histones. eLife, e49038
Esin A, Bergendahl LT, Savolainen V, Marsh JA, Warnecke T. (2018). The genetic basis of red blood cell sickling in deer. Nature Ecology & Evolution 2(2), 367-376.
Rudan M, Bou Dib P, Musa M, Kanunnikau M, Sobočanec S, Rueda D, Warnecke T, Krisko A. (2018). Normal mitochondrial function in Saccharomyces cerevisiae has become dependent on inefficient splicing. eLife e35330.
Ruden M, Schneider D, Warnecke T, Krisko A. (2015). RNA chpaerones buffer deleterious mutations in E. coli. eLife (4), e04745.
