The Telomere Replication & Stability group is looking to recruit a motivated and highly creative Postdoctoral Scientist interested in investigating the role of human Telomere factors in facilitating telomere replication and protecting chromosome ends using biochemical and cryo-EM approaches. This 2-year postdoctoral position is available at the MRC London Institute of Medical Sciences (LMS) based on the Hammersmith Hospital Campus of Imperial College London. The LMS has first class facilities and provides investigators with the opportunity to pursue innovative, multidisciplinary research within the excellence of Imperial College London. The objective of the group is to study the molecular dynamics of DNA secondary structures during mammalian DNA replication The main aim of the project is to discover the structural basis of Shelterin and its associated factors on telomeric DNA. In addition, the postdoc will work with other team members to investigate the effect of mutation associated human disease in shelterin stability. The human proteins will be expressed in human or insect cells and purified by affinity chromatography.

Based in West London, the MRC London Institute of Medical Sciences (LMS) is an Institute of the Medical Research Council and an academic division of the Faculty of Medicine, Imperial College London. Research activity is organised around three major themes: Epigenetics, Integrative Biology and Genes and Metabolism, addressing key questions underpinning human health and disease.
Research at the LMS covers a wide range of topics and is supported by a well equipped and expanding light microscopy facility which comprises a large variety of systems ranging from stereo microscopes and slide scanners to the latest confocal, super-resolution and light sheets instruments. We are seeking a motivated and enthusiastic individual who will provide training and technical support for our large user base as well as performing routine maintenance and troubleshooting on the different imaging platforms. Direct participation in research projects is also encouraged.

The Chain Florey Clinical Research Fellowship Scheme presents clinical trainees with a unique opportunity to study basic science supported by two world-renowned academic institutions, Imperial College and the Medical Research Council London Institute of Medical Sciences (LMS), formerly the Clinical Sciences Centre. The scheme has a variety of PhD projects on offer which focus specifically on basic science rather than on clinical research.
Chain Florey Clinical Research Fellowships provide an ideal base for those wishing to pursue a career in clinical academia. You should possess prior laboratory experience and need to demonstrate the skill base and motivation for a basic science PhD; each Fellow is expected to complete their PhD within the duration of the appointment.