Breaking the S-ENesence CODE “S-ENCODE: Towards Senescence Reversal and Therapeutic Opportunities.

Cellular senescence limits the proliferation of dysfunctional cells in response to diverse forms of cellular stress, playing essential roles in tumor suppression and tissue regeneration, while also contributing to age-related pathologies. Here, we will discuss our latest results using multidimensional profiling to define the temporal organization of the senescence transcriptional program, the transcription factor network topology that controls it and its underlying epigenome dynamics. Together, our findings identify dynamically regulated chromatin transitions critical for senescence commitment, thus hinting at promising targets for manipulating the senescence program for therapeutic benefit.

 

Oliver Bischof

Pasteur Institute