Molecular Systems

“Our goal is to understand how what is happening inside the cell biases the incidence of mutations, affects their persistence, and, ultimately, shapes patterns of natural variation within and between species.”

Some of the questions we have been working on include:

We address these questions using both computational and experimental approaches. This often involves combining genome-wide experimental data on intermolecular interactions – between different proteins, between proteins and RNA, and between proteins and DNA – with structural, kinetic, and of course evolutionary data. With the overarching aim of establishing how the workings of the cell condition the evolutionary process, our research is not tied to a particular biological system. Rather, we flexibly exploit different systems, from humans and yeast to bacteria and archaea, often in a comparative context.

Selected Publications

Hocher A, Rojec M, Swadling JB, Esin A, Warnecke T. (2019). The DNA-binding protein HTa from Thermoplasma acidophilum is an archaeal histone analog. eLife, e52542

Rojec M, Hocher A, Stevens KM, Merkenschlager M, Warnecke T. (2019). Chromatinization of Escherichia coli with archaeal histones. eLife, e49038

Esin A, Bergendahl LT, Savolainen V, Marsh JA, Warnecke T. (2018). The genetic basis of red blood cell sickling in deer. Nature Ecology & Evolution 2(2), 367-376.

Rudan M, Bou Dib P, Musa M, Kanunnikau M, Sobočanec S, Rueda D, Warnecke T, Krisko A. (2018). Normal mitochondrial function in Saccharomyces cerevisiae has become dependent on inefficient splicing. eLife e35330.

Ruden M, Schneider D, Warnecke T, Krisko A. (2015). RNA chpaerones buffer deleterious mutations in E. coli. eLife (4), e04745.